Antigen-specific therapy of multiple sclerosis: The long-sought magic bullet

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Beyond the magic bullet

that scholars and medical men alike have been fooled by a series of attributions devised by Dioscorides and Artemidorus Capito c. A.D. 125 and given greater and almost unshakeable authority by the verbose, argumentative, and persuasive Galen. The main thesis, that the interest in "the true doctrines of Hippocrates" postdates Erasistratus and is the result of the cataloguing in the Alexandrian l...

متن کامل

Antigen-specific tolerization approaches in multiple sclerosis.

INTRODUCTION Inhibition of self-reactive T cells through induction of antigen-specific immune tolerance holds the promise of effective treatment of autoimmune pathology with few side effects and preservation of normal immune functions. In multiple sclerosis (MS) several approaches have been tested already in clinical trials or are currently ongoing with the aim to inhibit myelin-reactive immune...

متن کامل

Magic bullet: the history of oral rehydration therapy.

In February 1994, the directors of major United Nations agencies, the Prime Minister of Bangladesh, medical researchers, international health advocates and politicians gathered in Dacca, Bangladesh, to celebrate the twenty-fifth anniversary of a life-saving technique known as oral rehydration therapy (ORT). UNICEF and the International Centre for Diarrhoeal Disease Research organized the meetin...

متن کامل

Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis?

Modulatory cytokines such as IL-4 and IL-10 looked promising biologicals, but suffered from poor exposure at the inflamed joints when administered via the patient-friendly subcutaneous route. Immunocytokines have now been engineered with tissue targeting potential and are a possible solution to this problem, although challenges still exist. Local inflammatory processes cause destruction of extr...

متن کامل

The coming of age for antigen-specific therapy of multiple sclerosis.

There is a compelling need for novel approaches for treatment of multiple sclerosis (MS). Although there are some approved therapies for MS, the efficacy of these current treatments leaves ample room for improvement. For example, the data from the pivotal trials leading to the approval of the beta-interferons and glatiramer acetate revealed that relapse rates were reduced by about a third, in p...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Neurotherapeutics

سال: 2007

ISSN: 1933-7213,1878-7479

DOI: 10.1016/j.nurt.2007.07.007